AMC-109 effectively eliminates biofilms

The manufacture of AMC-109 has been optimized and represents a scalable cGMP process with defined lead-times.

Parameter	Description
Molecular Formula	C₄₃ H₇₂ C_l3 N₁₁ O₃
Molecular weight	788.09(average mass,net)
Molecular weight	897.46(average mass,tri HCl salt)
Salt form	Hydrochloride
Physical appearance	White to pale yellow solid
Chirality	AMC-109 drug substance is a non-racemic chiral compound containing three stereo centres
Melting point	N/A
Solubility	>70mg/mL in water >50mg/mL in methanol

AMC-109 is degradable into simple amino acids.

AMC-109 –Broad Spectrum and Rapid Antimicrobial Activity

A characteristic feature of AMC-109 is its broad spectrum of activity, often spanning both gram-negative and -positive bacteria and in some cases even fungi.

Efficacy has been demonstrated against a wide range of organisms including:

Gram-positive bacteria
Most Gram-negative bacteria
Fungi

Furthermore, AMC-109 is equally effective against antibiotic-susceptible and -resistant strains:

Methicillin-resistant Staphococcus Aureus (MRSA)
Vancomycin-Resistant enterococci (VRE)
Multi-resistant Pseudomonas isolates

Strain	Number of isolates	MICs(mcg/ml)
Staphylococcus	6	2-7
MRSA	6	4-8
Coagulase neg. S.aureus	4	1-8
Streptococci	24	8-32
Enterocci	9	4-16
Cornyebacterium	2	8-16
Pseudomonas	109	8-32
Escherichia coli	3	8
Enterobacter	2	4-16
H.influenzae	3	8
Candida	5	4-16
Other fungi	20	4-64

Another characteristic of AMC-109 is the rapid kill kinetics compared with traditional antibiotics.

amc-109c

Rapid in vitro kill kinetics of AMC-109 Staphylococcus aureus strain FDA486.

Live (green) and dead (red) Staphylococcus aureus bacteria incubated with AMC-109

Bandage containing AMC-109 prevents growth of Staphylococcus aureus

Plates inoculated with Staphylococcus aureus. Bandage patches impregnated with 1 mg or 2 mg AMC-109 and placed on top agar plates.

Inhibition of bacteria growth under and around bandage with AMC-109